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I have just been told that my prostate cancer is now hormone-refractory and my oncologist suggested that I go on a drug called ketoconazole and hydrocortisone. Do you think it might help me?

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I have just been told that my prostate cancer is now hormone-refractory and my oncologist suggested that I go on a drug called ketoconazole and hydrocortisone. Do you think it might help me?

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Yes. A number of studies have found this secondary hormonal (it is an antifungal drug with both direct tumor cell killing and androgen depleting effects) therapy gives a favorable response rate between 30 percent and 63 percent. One study showed that those patients who had a greater than 50 percent decrease in PSA while receiving ketoconazole experience a longer survival time (41 months versus 13 months) than those who did not.

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