I have heard that Clomid is not recommended for women over 40. Why?
As women pass 35, many doctors do begin to be more cautious about using it for a couple of reasons. One, women approaching 40 tend to have more lining problems and Clomid can have deleterious effects on the lining. Secondly, if a woman is perimenopausal, the mechanism by which Clomid works is not always effective, because the body is somewhat inured to low Estradiol levels.