I have CDI. The amount of vasopressin used each month has begun to increase dramatically * Should I be alarmed that I am requiring higher doses of vasopressin than before?
An increase in the requirement for vasopressin (or dDAVP) is not necessarily a cause for alarm unless it gets way above the normal range. Usually, it only indicates that the drug has gone bad or is not being given or absorbed optimally. This can occur for a variety of reasons, and you should discuss this with your doctor or specialist. If that does not solve the problem and you are really taking vasopressin (and not the analogue dDAVP) in abnormally high doses, it is also possible that you have developed antibodies. If so, you may want to switch to dDAVP or chlorpropamide since they are usually not affected by the antibodies.
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