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I have been taking Arimidex® (anastrozole) after adjuvant chemotherapy for breast cancer for about 5 years. Should I stop taking it as my physician advises?

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I have been taking Arimidex® (anastrozole) after adjuvant chemotherapy for breast cancer for about 5 years. Should I stop taking it as my physician advises?

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You should take the advice of your physician. Anastrozole was compared with tamoxifen alone or in a combination of tamoxifen with anastrozole in a large randomized trial involving 9,000 women. That trial established the superiority of single-agent anastrozole and made it one of the standard approaches in treatment of postmenopausal woman with hormone receptor-positive early-stage breast cancer. There are some recent efforts to study additional benefit after 5 years of aromatase inhibitor, but those data are not mature yet.

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