I have been on Femara® (letrozole) for 3 years. Should I switch to tamoxifen at the end of 5 years of letrozole to get the benefits of both?
The sequence of switching from tamoxifen to an aromatase inhibitor, such as letrozole, Arimidex® (anastrozole), or Aromasin® (exemestane), versus the opposite sequential approach is currently the subject of clinical trials. What seems likely is that 5 years of antihormonal therapy in postmenopausal women may not be optimal and longer duration might be better, but there is no conclusive evidence to date. You should discuss this with your oncologist.
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