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I have a partial molecular replacement solution for my data and also a single derivative. Should I bother trying to calculate phases from the derivative?

April 26, 2017bother CALCULATE Data derivative Molecular partial replacement solution

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I have a partial molecular replacement solution for my data and also a single derivative. Should I bother trying to calculate phases from the derivative?

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A. Yes. Any experimental phase information you can obtain will make model building (using phase combined maps) and refinement (using the MLHL target) easier. Remember that the experimental phases will be as unbiased as you can hope for (the molecular replacement phases will not be). You could use the phases from the partial molecular replacement model as prior phase information in your SIR phasing.