I am currently using raloxifene (brand name: Evista) along with tamoxifen for breast cancer chemoprevention. Is raloxifene metabolized in the same way as tamoxifen (using 2D6)?
Raloxifene is not metabolized by 2D6 or any of the other cytochrome P450 enzymes, thus 2D6 testing is not relevant to your response to Raloxifene. At this time, there is no genetic test that will determine the effectiveness of raloxifene. Other alternatives to tamoxifen, called aromatase inhibitors, also do not have a genetic test to predict their effectiveness at this time.
Related Questions
- I am currently using raloxifene (brand name: Evista) along with tamoxifen for breast cancer chemoprevention. Is raloxifene metabolized in the same way as tamoxifen (using 2D6)?
- Should postmenopausal women at increased risk of breast cancer take raloxifene or tamoxifen based on these results?
- What determined which participants received tamoxifen or raloxifene?
