I am being treated with Bexarotene and my thyroid stopped working. What is going on?
Bexarotene is a synthetic retinoid X receptor (RXR)-selective retinoid used in the treatment of cutaneous T-cell lymphoma. Bexarotene causes hypothyroidism by reducing levels of both thyroid-stimulating hormone (TSH) and thyroxine, and treatment may require relatively high levels of thyroxine. See Etiology, diagnosis, and treatment recommendations for central hypothyroidism associated with bexarotene therapy for cutaneous T-cell lymphoma. Clin Lymphoma. 2003 Mar;3(4):249-52.