How will the high-throughput centers select their targets?
A. The first and third target selection goals (structural coverage of sequenced genes and consideration of targets proposed by the scientific community) are PSI network activities. Each center must identify groups of proteins that the center will work on in meeting these goals. Under terms of the cooperative agreement, all PSI:Biology centers will work with NIH staff to select targets to meet these goals and to determine each center’s tasks. The second goal (structural genomics research project with a significant biomedical theme) is an individual activity for the large-scale centers. Each center will select targets that will lead to unique, non-redundant protein structures that addresses the center’s chosen scientific problem.
