How will PROMISE and RESCUE change clinical care?
Because RESCUE requires initial medical treatment and excludes revascularization (except in patients with left main coronary artery disease), it is most suited to inform care when a ‘COURAGE-like’ optimal medical treatment-only approach is being followed. By mandating the post testing treatment options, RESCUE is focused on the comparison of two diagnostic imaging-treatment paradigms in guiding a predominantly non interventional treatment strategy. RESCUE is specifically designed to answer a number of questions posed in the Consensus Report on Initial National Priorities for Comparative Effectiveness Research (CER) issued by the Institute of Medicine (IOM), and the results of this trial are of interest to CMS. On the other hand, because PROMISE does not place any restrictions on additional testing, medical treatment or revascularization after the initial study, it is most suited to inform situations in which usual care is offered to patients with symptoms suggestive of CAD, including P
