How will NMR participate in biomarker ID?
GM: Biomarkers are analogous to drug impurities and degradation products. The primary difference is the matrix from which they’re being extracted. Once you have any type of trace sample in hand, the structural characterization of it becomes fundamentally the same. RR: What contributions to NMR are you most proud of? GM: This obviously goes in part back to small volume high sensitivity probes, but also to experimental methods contributions including long-range 1H-15N and accordion optimized long-range experiments. RR: Are there any new industries that could benefit from NMR? GM: There are a couple of factors associated with NMR spectroscopy that in my opinion tend to inhibit its use as an “analytical” technique. To begin with, most NMR hardware isn’t cheap and requires a skilled instrument operator to select the experiments to be performed to answer a specific structural question and then to acquire the necessary data. That operator, or a colleague, must also be capable of interpreting
