How were the annotations done? How reliable are they?
The current annotation of the genome sequence is described in Adams et al. 2000 and Rubin et al. 2000 The sequence was annotated at Celera at an ‘Annotation Jamboree’ using gene prediction programs and limited human curation. Over the next six months to one year, the BDGP will finish the sequence to the Phase III standard. As finishing is completed for an interval, that interval will be re-annotated; when an entire arm is finished and re-annotated, there will be a new release of that arm. Between now and then, we need your help! You will undoubtedly notice errors in the sequence and mistakes in the annotations. Help us to correct them by sending us an Error Report. We will post your comments as additions to the gene annotation record and, when we reach that part of the genome, we will use them as an aid in the finishing process and to correct gene annotations. Treat the current annotations with skepticism. The annotations were done using a combination of gene prediction programs and li
