How to choose liposomes with the appropriate lipid chain length?
There are various factors when choosing a lipid chain length. The primary function of the lipid bilayers is to act as a drug permeation barrier. The longer the lipid chains the tighter the bilayers. The most commonly used liposomes are DSPC or HSPC based. However, when the drug retention still falls short, longer chain lipid could be considered. We have PEGylated and non-PEGylated 20:0PC, 22:0PC and even 24:0PC liposomes.
