How should Wellbutrin / Bupropion SR be used?
It is usually taken twice a day, with doses at least 8 hours apart. Bupropion SR should be taken exactly as directed. Patients should not take more or less of it or take it more often than prescribed by their doctor. The sustained-release tablets should be swallowed whole (do not split, chew, or crush them). Wellbutrin/Bupropion-SR compared to regular Bupropion Compared with Bupropion, the SR formulation is said to demonstrate similar efficacy and has been found to have similar, but to some degree fewer, side effects. Its efficacy is said to be similar to that of other newer antidepressants. Side effects of bupropion SR are limited and are not dissimilar to those of the serotonergic antidepressants; however, bupropion SR does not apparently produce substantial sexual side effects nor drug interactions. Study data demonstrate that seizure incidence, which is a concern with high-dose regular Bupropion, is substantially lower with Bupropion SR.
