How should Orfadin be stored?
ADMINISTRATION AND DOSAGE (questions 11-18) 11. How is it dosed? (Treatment should be initiated by a physician experienced in the treatment of hereditary tyrosinemia type 1) The dose of nitisinone should be adjusted in each patient. The recommended initial dose is 1mg/kg/day divided for morning and evening administration. 12. Can it be taken with food? Since an effect of food is unknown, nitisinone should be taken at least one hour before a meal 13. How can it be given to infants and children too small to swallow a capsule? For young children, capsules may be opened and the contents suspended in a small amount of water, formula, or apple sauce immediately before use 14. What kind of diet should I prescribe for the child? A nutritionist skilled in managing children with inborn errors of metabolism should be employed to design a low-protein diet deficient in tyrosine and phenylalanine 15. How and when do you adjust (titrate) the dosage? Treatment should lead to normalized porphyrin metab
