How should Lamictal (Lamotrigine) be taken?
The initial dose of lamictal in patients, not taking valproic acid (Depakote), is 50 mg once daily for two weeks, followed by 100 mg daily, given in two divided doses for two weeks. Thereafter, the usual maintenance dose is 300 to 500 mg daily, given in two divided doses. In patients taking valproic acid, the initial dose of lamictal is 25 mg every other day for two weeks, then 25 mg once daily for two weeks, slowly increasing the dose (by 25 to 50 mg per day) every one to two weeks) until a dose of 100 to 150 mg daily is reached. Standard doses of lamictal are given twice daily.
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