How should dose adjustments be made?
Daily dose should be tailored to individual response and therapeutic goals (maintenance or reduction of total body iron) in increments of 5 mg/kg or 10 mg/kg based on serum ferritin trends and transfusion history. If serum ferritin falls consistently below 500 mcg/L, consideration should be given to temporarily interrupting therapy with EXJADE. The risk of toxicity of EXJADE may be increased when inappropriately high doses are given to patients with low iron burden or with serum ferritin levels that are only slightly elevated. In patients not adequately controlled with doses of 30 mg/kg (eg, serum ferritin levels persistently above 2500 mcg/L and not showing a decreasing trend over time), doses of up to 40 mg/kg may be considered. Doses above 40 mg/kg are not recommended.1 Increase the dose of EXJADE and monitor serum ferritin levels and clinical response for further dose modification when it is used concomitantly with potent UGT inducers (eg, rifampicin, phenytoin, phenobarbital, rito
