How should dose adjustments be made based on serum ferritin?
Daily dose should be tailored to individual response and therapeutic goals (maintenance or reduction of total body iron). EXJADE may require dose adjustment, interruption, or cessation of therapy. Make dose adjustments in increments of 5 mg/kg or 10 mg/kg based on serum ferritin trends. In patients not adequately controlled with doses of 30 mg/kg (eg, serum ferritin levels persistently above 2500 mcg/L and not showing a decreasing trend over time), doses of up to 40 mg/kg may be considered. If serum ferritin falls consistently below 500 mcg/L, consideration should be given to temporarily interrupting therapy with EXJADE. Increase the dose of EXJADE to 30 mg/kg/day, and monitor serum ferritin levels and clinical response for further dose modification when it is used concomitantly with potent UGT inducers (eg, rifampicin, pheytoin, phenobarbital, ritonavir) or cholestyramine.Doses above 40 mg/kg are not recommended. Gastrointestinal symptoms, increases in serum ferritin, and skin rash we
