How serious is a brown recluse spider bite?
Here Are Some Facts And Classifications On A Brown Recluse Spider Bite: Bites and envenomation range from a mild, local, urticarial reaction to full-thickness necrosis. The venom volume is minute, about 4 µL, with 65-100 mcg of protein. The venom contains alkaline phosphatase, 5’ribonucleotide phosphohydrolase, esterase, lipase, hyaluronidase, and, most importantly, sphingomyelinase D2. Sphingomyelinase D2 is responsible for calcium-dependent direct erythrocyte lysis. The degree of hemolysis is individually variable from 20% to more than 95%. Cutaneous necrosis is completely dependent on activation of neutrophils. In rabbit studies, neutrophil infiltration occurs at 6 hours. Neutrophils significantly accumulate at 24-72 hours, preceding skin necrosis and ulceration. This explains why early dapsone initiation may be important to limit necrosis in bites destined for that reaction. Frequency United States In 1994, 1835 brown recluse spider bites were reported to poison control centers nat
