How Safe Are COX-2 Inhibitors in NSAID-sensitive Subjects with Cutaneous Reactions?
Mario Snchez-Borges, Arnaldo Capriles-Hulett, Fernan Caballero-Fonseca Allergy-Immunology Service, Centro Mdico-Docente La Trinidad, Caracas, Venezuela (postal address P.O.B.A. International #635, Miami 33102-5255, Florida) (49 KB) Abstract Background: This article summarizes the published information concerning the utilization of the new preferential and selective non-steroidal anti-inflammatory agents in patients intolerant to the classic inhibitors of cyclooxygenase-1 (COX-1). Methods/Data base: A review of the literature. Results/Conclusions: Among drugs presently being used the most selective inhibitors of COX-2, such as the coxibs Rofe-coxib and Celecoxib appear to be safe alternative medications for those subjects who experience aspirin-exacerbated respiratory disease or the cutaneous reactions of urticaria or an-gioedema. These observations lend support to the concept that above mentioned adverse reactions to NSAIDs are mediated through inhibition of COX-1. Allergy Clin Immunol
