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How or can a doctor tell if prostate cancer is confined to the prostate from a biopsy if the biopsy doesn include tissue surrounding and outside the prostate?

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How or can a doctor tell if prostate cancer is confined to the prostate from a biopsy if the biopsy doesn include tissue surrounding and outside the prostate?

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One cannot tell for certain. The doctor is guided by the findings on digital rectal examination, trans-rectal ultrasonography performed in conjunction with the biopsy, abdominal-pelvic CT or MRI scan, bone scan, PSA level, Gleason grade, and amount of cancer present in the biopsy cores.

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