How often does the BUA need to be renewed?
BUAs are approved for three years. Three to four months before the BUA expires, the Biological Safety Office will email the principal investigator a new BUA application along with the current BUA and BUA amendments so that the principal investigator can submit a renewal BUA. A renewal BUA should describe all aspects of your current project including relevant information from the original BUA plus relevant portions of subsequent amendments, plus proposed new work on the same project. BUA Amendments: For personnel additions or deletions, procedures, work locations, or agents/materials during the term of the BUA, a BUA Amendment that documents the changes must be submitted to the Biological Safety Office for IBC review. A “major change” in experimental direction for a project already described on an approved BUA requires a new risk assessment and documentation as a major change amendment. Use the standard BUA form for “major change amendments”.
