How much solution should be withdrawn from a bag before adding a cytotoxic drug?
The volume to be withdrawn from a bag depends on the original bag size and the volume of drug that is to be added. Solution bags are quite flexible and allow fairly large volumes to be added without difficulty. The intention of prior withdrawal is to ensure that the final volume of the bag is not so large that administration is difficult and that there is no risk of the bag rupturing. If the volume of drug to be added is small enough, no prior withdrawal is required. The table below provides an example of the guidelines used by the Vancouver Centre to determine the volume to be withdrawn from a bag prior to adding cytotoxic drug. Please note that this is an example only. Other BC Cancer Agency (BCCA) Centres may use slightly different procedures.
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