How much seroquel does it take to overdose?
Mr. A was a 52-year-old white man with chronic paranoid schizophrenia and a history significant for multiple psychiatric hospitalizations, poor response to neuroleptic therapy, and irregular medication compliance. His history was also significant for overdosing, usually during attempts at self-adjustment of medications. After an overdose of risperidone in the past, he was noted to have a QT interval of 496 msec. Mr. A’s medical history was significant for cardiac dysrhythmia and hypertension, which were managed with felodipine, 10 mg/day. His psychiatric medications were 600 mg/day of quetiapine, 100 mg/day of sertraline, 20 mg of buspirone t.i.d., and 50 mg of haloperidol decanoate by intramuscular injection every 2 weeks. On the day of the overdose, Mr. A was discovered to be comatose, presumably a few hours after ingestion of the quetiapine, and in acute respiratory distress. Resuscitation efforts by paramedics were unsuccessful. An autopsy revealed cardiomegaly, with left ventricul
