How much iterative structural work to derive detailed mechanistic information beyond a first pass structure of a given protein target is expected?
A. One goal of the PSI remains the solution of novel protein structures. However, additional structures necessary to establish function, such as structures with bound ligands subsequently identified by the partners may be undertaken. But it is not expected that detailed structure/function studies involving many mutants and series of substrate analogs and inhibitors will be undertaken within the PSI:Biology initiative.
Related Questions
- How much iterative structural work to derive detailed mechanistic information beyond a first pass structure of a given protein target is expected?
- When I complete my course assessments/qualifications, what grading is given e.g. pass or fail?
- How many amino-acid sequences can fold to a given protein structure?
