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How much DNA degradation occurs in bisulfite conversion?

April 26, 2017bisulfite conversion degradation dna occurs

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How much DNA degradation occurs in bisulfite conversion?

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Depending on the quality of the input DNA and which procedure is used (one step vs. two step), degradation can be as low as 40% or as high as 90 – 100%. This modification method is inherently very harsh so degradation will always occur to some extent.