How might Aspirin work in colon cancer prevention?
We think it works by its ability to block what is known as the COX-2 enzyme, something that exists in the majority of colorectal tumour cells but is absent in healthy colorectal tissue. The theory is that COX-2 inhibition reduces the progression of tumours that rely on this enzyme for their development. What are the non-cancer benefits and risks of Aspirin? Daily low-dose Aspirin is perhaps best known for its role in cardiovascular disease, specifically for the prevention of a first or subsequent heart attack and stroke. As a blood thinner, Aspirin makes platelets less likely to form a clot, thereby reducing the risk of a blocked artery. For all its “wonder drug” benefits, however, there are some risks associated with Aspirin. These include an increased risk of bleeding from the intestines or even inside the brain, both of which are potentially life-threatening side effects. The study Rothwell PM, Wilson M, Elwin CE et al. Long-term effect of Aspirin on colorectal cancer incidence and
