How many women were affected by disease events?
Referring to the graph on the WHI Hormone Program Update (2004), for every 10,000 women taking CEE each year, there were: • 12 more strokes. (There were 44 strokes per 10,000 women per year in the CEE group and 32 strokes per 10,000 women per year in the placebo group.) • 7 more blood clots to the legs and lungs combined (28 CEE, 21 placebo)—these effects are considered uncertain. • 3 more deaths (81 CEE, 78 placebo)—these effects are neutral (no effect of CEE). • 1 more colorectal cancer (17 CEE, 16 placebo)—neutral. • 5 fewer heart attacks (49 CEE, 54 placebo)—neutral. • 7 fewer invasive breast cancers (26 CEE, 33 placebo)—uncertain. • 6 fewer hip fractures (11 CEE, 17 placebo)—benefit. Not shown on the Update graph were 56 fewer total fractures. Analysis of the data included a “global index” for assessing the balance of risks and benefits overall. The global index compares the number of women who had any of the following serious health conditions: heart attacks, stroke, blood clots
