How many units of PolyHeme® have been given to patients previously?
Northfield has experience with PolyHeme® in patients with acute blood loss in trauma and elective surgery in the hospital setting, including those who have received up to 20 units (pints) containing 1,000 gm of PolyHeme®. The normal volume of blood in a human is 10 units (pints) containing 500 gm of hemoglobin. This means that up to two times the normal volume of blood in a human has been replaced by PolyHeme®. Some of these patients were kept alive while losing virtually all of their own blood during ongoing bleeding and receiving only PolyHeme® as replacement. Observations in these patients have suggested the life-sustaining potential of PolyHeme® in the treatment of urgent life-threatening blood loss and life-threatening hemoglobin levels [Gould et al, Journal of American College of Surgeons (2002), Volume 195 (4)].