How many more MGUS patients will be detected using sFLC assays?
MGUS have historically comprised intact immunoglobulins and these are detected using SPE. FLC only MGUS have been observed in the urine but only rarely. FLC MGUS have recently been detected in serum using FLC immunoassays at a frequency of approximately 20% of intact immunoglobulin MGUS (3% of samples from individuals over 70 years of age). Since MGUS comprises 60-80% of monoclonal gammopathies, many new FLC MGUS patients will be detected. These may be the precursor of LCMM and AL amyloidosis and are a focus of considerable clinical interest.
