How many mice should be analyzed to indentify QTL?
The number of mice that should be analyzed depends on the variance of the phenotype(s) under study and the expected QTL effect(s). Generally, we suggest genotyping 200-300 mice. Alternatively, only mice with extreme phenotypes (about 60-70% of the total progeny) may be genotyped. To select this supset, we suggest phenotyping all the progeny.
