How many chemical compounds will be in public sector libraries?
To provide maximum benefits, the library of small molecules must contain a sufficient number of compounds to be screened for a large number of possible new activities and applications. To build such a library, a network of national centers will initially establish a collection of 500,000 chemically diverse small molecules, of both known and unknown activities. Over time, this collection will be expanded and modified to provide a working set of compounds that will target larger domains of “biological space,” the total set of biomolecular surface domains capable of interacting with a small molecule.
