How long should I wait to give MMR after a dose of immune globulin?
High doses of immune globulins can inhibit the immune response to measles and rubella vaccine for 3 or more months. The duration of this interference with the immune response depends on the dose of immune globulin administered. Blood (e.g., whole blood, packed red blood cells, and plasma) and other antibody-containing blood products (e.g., IG, specific immune globulins, and IGIV) can reduce the immune response to MMR or its component vaccines. Therefore, these vaccines should be administered to persons who have received an immune globulin preparation only after the recommended intervals have elapsed. Table 4 in the ACIP General Recommendations provides suggested intervals between the administration of antibody-containing products for different indications and measles-containing vaccine or varicella vaccine.
