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How long does Zoloft take to work?

April 26, 2017Health mental mental health Zoloft

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How long does Zoloft take to work?

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It sounds like Zoloft may not be the answer for you. I have been on Zoloft two times now and both times it started working right away. I felt this positive glow from the first day on. Long-term effects (like other people noticing positive changes in you) usually take a month or two.