How long does nicotine stay in the body?
85–90 percent of nicotine in the blood is metabolized by the liver and excreted from the kidney rapidly. The estimated “life” for nicotine in the blood is about two hours. However, smoking represents a multiple dosing situation with considerable accumulation during smoking. So, blood nicotine can persist at significant levels for 6 – 8 hours after the last puff.
