How long does it take to see an appreciable response to an antidepressant medication?
It may take several weeks to see an appreciable response to an antidepressant medication. The practitioner should assess the patient’s response within 2 weeks of initiating therapy. Informed decisions about changing or continuing treatment may be made after 4 weeks and again after 6 weeks. • Do older patients have an increased sensitivity to pharmacologic therapy then younger patients? Older patients in general are more sensitive than younger adults to the adverse effects of antidepressant medications. However, to obtain a therapeutic response, older patients require drug concentrations similar to those that generally produce a therapeutic response in younger patients. • Are any class of antidepressants more effective than the others? No single class of antidepressant has been found to be more effective than another in the acute treatment of late-life depression. TCAs, SSRIs, and selective noradrenergic reuptake inhibitors (SNRIs) are all effective. Following the era of TCAs, SSRIs qui
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