How long does it take to feel beter once you start taking Zoloft?
All medicines for depression, panic disorder, OCD, and PTSD take time to work. Zoloft usually takes 2 to 4 weeks to begin to work. Sometimes it takes as long as 6 to 8 weeks to feel better. People who take Zoloft should not expect to feel better right away. It is important to keep taking Zoloft as directed by your doctor. People around you may see changes in you before you do.
