How long does dDAVP last in the body?
The body does not store dDAVP, but it can accumulate if it is given faster than the body disposes of it. The half-life varies markedly from person to person but averages around 1 to 2 hours. The antidiuretic effect of the usual intranasal dose also lasts for variable periods of time not only because of variations in half-life but also in absorption of the drug. On average, however, it is about 8 to 12 hours, or 4 to 6 half lives, because the initial blood levels achieved are greater than necessary to produce antidiuresis.
