How is Vetmedin different from digoxin?
A The failing heart has been shown to have impaired calcium management so that the increase in intracellular calcium brought about by digoxin actually increases energy consumption and oxygen requirements. This may also lead to impaired relaxation and arrhythmias. Vetmedin does not lead to an increase in intracellular calcium ions and therefore does not increase oxygen demand. Vetmedin does not impair relaxation. To date, no studies have demonstrated an increase in arrhythmias.
