How is treatment with lamotrigine initiated?
In people not taking carbamazepine or valproate, lamotrigine is usually initially prescribed at an initial dose of 25 mg once or twice a day and the dose increased by 25 or 50 mg every week or two. In people taking valproate the initial dose of lamotrigine is often 12.5 mg/day and the drug is increased by 12.5 or 25 mg every two weeks. In people taking carbamazepine somewhat larger initial doses and more rapid increases in dose are possible. 10.
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