How is this RFA related to the overall Roadmap Epigenomics Program?
The four Roadmap Epigenomics Program RFAs released in 2008 – Epigenomics Mapping Centers, Epigenomics Data Coordinating Center, Technology Development RFAs, and Discovery RFAs – provide the fundamental scientific data and tools to accelerate research aimed at understanding the epigenetic contributions to human disease. The purpose of this RFA on the Epigenomics of Disease is to begin to capitalize on these findings and support novel research that transforms our understanding of the epigenetic structure and mechanisms underlying specific diseases or disease-related processes, states, or conditions. Applicants should conduct global (epigenome-wide) mapping in diseased, aged, or environmentally compromised human cells or tissues, and in comparative “healthy” control cells or tissues. Applicants may also conduct follow-up targeted (epigenetic) analyses to begin to elucidate mechanisms of disease etiology. Follow-up studies, if proposed, should be based on results from the mapping analysis.
