How is therapy with Argatroban monitored and adjusted?
In general, therapy with Argatroban is monitored using the aPTT. Steady-state anticoagulant effects (including the aPTT) typically occur within 1 to 3 hours following initiation of Argatroban. Dose adjustment may be required to attain the target aPTT. Check the aPTT 2 hours after initiation of therapy to confirm the patient has attained the desired therapeutic range.
