How is the parallel tube models hepatic clearance calculated?
A. We calculate hepatic clearance according to the parallel tube model (see “Theoretical considerations of a ‘well-stirred’ model and a ‘parallel tube’ model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic blood clearance” – Pang K S, Rowland M., J. Pharmacokinet Biopharm, pp 625-653, 1977) using the following equation: where Qb is the hepatic blood flow, bpr the blood:plasma ratio, fuplasma the fraction unbound in plasma, and Clint instrinsic clearance.
