How is the Membrane Dialysis Strips Molecular Weight Cut Off (MWCO) pore size determined?
Dialysis membranes consist of a matrix of cross-linked polymers. The pore rating, Molecular Weight Cut Off (MWCO), is an indirect measure of the retention performance using a series of standard molecules with varying molecular weights after 17 hours of dialysis. The membrane MWCO is determined as the solute size that is retained by at least 90%. However, since a solute’s permeability is also dependent upon molecular shape, degree of hydration, ionic charge and polarity, we recommend selecting a MWCO that is at least half the size of the MW of the species to be retained and/or twice the size of the MW of the species intended to pass through.
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