How is the gross mutation defined?
• Gross mutation triggers speciation, which is defined by its outcome: any modifications on the DNA structure will be the gross mutation, if it leads to failure of bivalent binding between the ancestral and descended haploid chromosomes. Most, if not all, chromosomal rearrangements, such as deletion, duplication, and translocation, are considered as the gross mutation. The gross mutation does not necessarily lead to gross physical changes of the involved organism.
