How is the dispersion models hepatic clearance calculated?
A. We calculate hepatic clearance according to the dispersion model (see “Correlation between in vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: analysis with a dispersion model” – Roberts M S, Rowland M., J Pharm Pharmacol pp 177-181, 1986) using the following equation: where Qb is the hepatic blood flow, bpr the blood:plasma ratio, fuplasma the fraction unbound in plasma, Clint instrinsic clearance, DN the dispersion number (assumed to be 0.17), and a and RN are defined by: , respectively.
