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How is the amount of airflow that must be removed from the containment zone to maintain negative pressure calculated?

April 26, 2017airflow calculated containment maintain negative pressure removed zone

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How is the amount of airflow that must be removed from the containment zone to maintain negative pressure calculated?

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The general rule of thumb is that at least 10% more air must be exhausted from the area than is supplied to it. For example, if 500 CFM is coming in through the facility HVAC system, then at least 550 CFM must be filtered and exhausted by the PAS.