How is the activated alpha-2-macroglobulin with all of the bound cytokines, antigens and proteins removed from the circulation?
The enzyme activated a2M, with the bound cytokines, antigens and proteins actually initiates its own removal (and the removal of the inflammatory substances) from the blood stream and uptake by macrophages. These macrophages are already in the circulatory system and in the spaces between cells. The enzyme activated alpha 2-macroglobulin promote macrophage locomotion and chemotaxis (movement initiated by a chemical message). The enzyme activated alpha 2-macroglobulin- complexes are cleared from the circulation very quickly by macrophages. The macrophages engulf, and then digest the cellular debris, excessive cytokines, bacteria, yeast, viruses, pollen, other allergens, excessive antibodies, excessive circulating immune complexes & other unwanted proteins that have been captured by the activated alph-2-macroglobulin. It is important to understand that if the cellular debris, excessive cytokines, bacteria, yeast, viruses, pollen, other allergens, excessive antibodies and the excessive cir
