How is TFP deficiency inherited?
TFP deficiency is inherited in an autosomal recessive manner. It affects both boys and girls equally. Everyone has a pair of genes that make the TFP enzyme group. In children with TFP deficiency, neither of these genes works correctly. These children inherit one non-working gene for the condition from each parent. Parents of children with TFP deficiency rarely have the disorder. Instead, each parent has a single non-working gene for TFP deficiency. They are called carriers. Carriers do not have TFP because the other gene of this pair is working correctly. When both parents are carriers, there is a 25% chance in each pregnancy for the child to have TFP deficiency. There is a 50% chance for the child to be a carrier, just like the parents. And, there is a 25% chance for the child to have two working genes.
