How is Tetramer staining affected by binding to CD8?
Beckman Coulter has obtained an exclusive license to utilize a mutated Class I in human and rhesus macaque iTAg MHC Tetramer manufacturing. This mutation greatly diminishes nonspecific MHC binding to CD8, but retains peptide specific MHC binding to TCR. For additional information, a reprint of the article Efficient detection and immunomagnetic sorting of specific T cells using multimers of MHC Class I and peptide with reduced CD8 binding by Bodinier, et al, published in Nature Medicine, Vol. 6, Number 6, June 2000, is available.
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